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Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

《化学科学与工程前沿（英文）》 2023年 第17卷 第7期   页码 966-975 doi: 10.1007/s11705-022-2244-1

摘要： The efficient utilization of natural lignin, which is the main by-product of the cellulose industry, is crucial for enhancing its economic value, alleviating the environmental burden, and improving ecological security. By taking advantage of the large sp2 hybrid domain of lignin and introducing amino functional groups, new lignin-derived carbon dots (SPN-CDs) with red fluorescence were successfully synthesized. Compared with green and blue fluorescent materials, red SPN-CDs have desirable anti-interference properties of short-wave background and exhibit superior luminescence stability. The SPN-CDs obtained exhibited sensitive and distinctive visible color with fluorescence-dual responses toward hypochlorite. Considering this feature, a portable, low-cost, and sensitive fluorescence sensing paper with a low limit of detection of 0.249 μmol∙L–1 was fabricated using the SPN-CDs for hypochlorite detection. Furthermore, a new type of visible-light and fluorescence dual-channel information encryption platform was constructed. Low-concentration hypochlorite can be employed as an accessible and efficient information encryption/decryption stimulus, as well as an information “eraser”, facilitating a safe and diversified transmission and convenient decryption of information. This work opens new avenues for high-value-added applications of lignin-based fluorescent materials.

关键词： alkali lignin     red light carbon dots     hypochlorite     encryption and anti-counterfeiting    

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增值税防伪税控系统及其安全性设计

魏庆福

《中国工程科学》 2000年 第2卷 第11期   页码 84-87

摘要：

增值税防伪税控系统是国家金税工程的主要组成部分之一，是为控管增值税、扼制利用发票偷税、骗税，防止税收流失而研制的。该系统采用数字密码技术，解决票据的防伪识伪，由微控制器、DSP和Flashi贮器构成的“黑盒子”和智能IC卡等技术集成，从税源的源头和票源的源头控制税收的征管。该技术发明的推广使用已成为辅助我国税收征管的强有力手段。它为解决国民经济中有关增值税征管中的重大难题作出了贡献。

系统为特殊的商用密码设备，运行环境极为恶劣，它既要防止国内外利益集团的集团攻击，又要抵御一些不法之徒，包括与税务部门内部人员勾结的个人攻击。为此，采用了一整套安全性设计技术，按照系统的安全模型，从核心硬件、密码算法、密钥管理、设备连接通道、运行环境、信息记录与审计、业务功能以及管理诸方面层层设防，综合治理。

关键词： 增值税     防伪     密码     安全性    

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基于钻头运动诱发套管头振动信号检测的井眼防碰监测方法

何保生,刘刚,王平双,文敏

《中国工程科学》 2011年 第13卷 第5期   页码 74-78

摘要：

针对海上加密调整井的井眼防碰问题，设计了一种井筒防碰地面监测预警系统，并进行了现场应用。系统利用加速度传感器监测通过套管传输到套管头上的钻头振动信号，利用数据采集、信号滤波放大和专门编制的监测软件记录分析传感器采集的振动信号，通过对信号的时域、频域分析，确定信号特征与井间相对距离的关系，识别钻头对风险井套管的趋近或碰撞。应用结果表明，该系统能有效感知通过地层、套管传输到套管头的钻头振动信号，并能识别出钻头对风险邻井的趋近，验证了系统在设计理论和方法上的可行性，为加密调整井的井眼防碰、保证钻井安全提供了一种有效的手段。

关键词： 调整井     防碰     风险井     振动信号     时域分析     频域分析    

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WLAN 802.11/11b数据加密机制的安全分析

宋宇波,胡爱群,蔡天佑

《中国工程科学》 2004年 第6卷 第10期   页码 32-38

摘要：

在802.11标准中的加密采用WEP协议，用于提供链路层数据传输的安全保护。目前，在原有EP的基础上提出了一些改进方案，能提高WEP的安全性能，但理论上缺少严密的安全分析。笔者通过数学模型对这些解决方案以及原有WEP协议进行量化分析，推导出机制内各模块与整个安全机制间安全性能的对应函数关系，并比较了这些方案间安全性能的差异，证明这些安全机制可以提高原有WEP的安全性能，在理论上为用户提供如何构造满足所需安全性能的WLAN数据加密增强机制。

关键词： WLAN     安全分析     WEP     密钥更新    

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MULKASE：一种针对多个所有者数据的新型密钥聚合可搜索加密方法 Regular Papers

Mukti PADHYA, Devesh C. JINWALA

《信息与电子工程前沿（英文）》 2019年 第20卷 第12期   页码 1717-1748 doi: 10.1631/FITEE.1800192

摘要： 最新密钥聚合可搜索加密（KASE）尝试将搜索加密数据与支持数据所有者相结合，共享一个聚合的可搜索密钥；该密钥授权用户搜索数据。相应地，用户需提交一个单一聚合陷门至云端，在共享数据集上执行关键词搜索。然而，现有KASE方法不支持使用单一聚合陷门在由多个所有者共享的数据上搜索。因此，本文提出MULKASE方法，该方法允许用户使用单一陷门在由多用户拥有的不同数据记录上搜索。在MULKASE方法中，聚合密钥尺寸不依赖于数据所有者拥有的文档数量，即使外包密文数量超出预定限值，聚合密钥尺寸维持不变。安全性分析证实MULKASE方法对所选消息攻击和关键词攻击安全，亦证实该方法对交叉配对攻击安全，且提供查询隐私。理论和实验分析表明MULKASE方法性能优于现有KASE方法。文中还演示了MULKASE方法如何执行联合搜索。

关键词： 可搜索加密；云存储；密钥聚合加密；数据共享    

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QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

《农业科学与工程前沿（英文）》 2023年 第10卷 第2期   页码 306-332 doi: 10.15302/J-FASE-2023488

摘要：

● Using visual analysis to predict the trend of natural product pest resistance.

关键词： anti-pest activity     crop protection     insect pest     natural product     visual analysis    

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Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

《医学前沿（英文）》 2023年 第17卷 第4期   页码 729-746 doi: 10.1007/s11684-022-0978-2

摘要： The effect of anti-programmed cell death 1 (anti-PD-1) immunotherapy is limited in patients with hepatocellular carcinoma (HCC). Yes-associated protein 1 (YAP1) expression increased in liver tumor cells in early HCC, and Akkermansia muciniphila abundance decreased in the colon. The response to anti-PD-1 treatment is associated with A. muciniphila abundance in many tumors. However, the interaction between A. muciniphila abundance and YAP1 expression remains unclear in HCC. Here, anti-PD-1 treatment decreased A. muciniphila abundance in the colon, but increased YAP1 expression in the tumor cells by mice with liver tumors in situ. Mechanistically, hepatocyte-specific Yap1 knockout (Yap1LKO) maintained bile acid homeostasis in the liver, resulting in an increased abundance of A. muciniphila in the colon. Yap1 knockout enhanced anti-PD-1 efficacy. Therefore, YAP1 inhibition is a potential target for increasing A. muciniphila abundance to promote anti-PD-1 efficacy in liver tumors. Dihydroartemisinin (DHA), acting as YAP1 inhibitor, increased A. muciniphila abundance to sensitize anti-PD-1 therapy. A. muciniphila by gavage increased the number and activation of CD8+ T cells in liver tumor niches during DHA treatment or combination with anti-PD-1. Our findings suggested that the combination anti-PD-1 with DHA is an effective strategy for liver tumor treatment.

关键词： hepatocellular carcinoma     YAP1     Akkermansia muciniphila     anti-PD-1     dihydroartemisinin     bile acid    

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A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0722-2

摘要： This paper proposes a novel modular cable-driven humanoid arm with anti-parallelogram mechanisms (APMs) and Bowden cables. The lightweight arm realizes the advantage of joint independence and the rational layout of the driving units on the base. First, this paper analyzes the kinematic performance of the APM and uses the rolling motion between two ellipses to approximate a pure-circular-rolling motion. Then, a novel type of one-degree-of-freedom (1-DOF) elbow joint is proposed based on this principle, which is also applied to design the 3-DOF wrist and shoulder joints. Next, Bowden cables are used to connect the joints and their driving units to obtain a modular cable-driven arm with excellent joint independence. After that, both the forward and inverse kinematics of the entire arm are analyzed. Last, a humanoid arm prototype was developed, and the assembly velocity, joint motion performance, joint stiffness, load carrying, typical humanoid arm movements, and repeatability were tested to verify the arm performance.

关键词： modular robotic arm     anti-parallelogram mechanism     Bowden cable     humanoid arm     lightweight joint design    

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Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

《化学科学与工程前沿（英文）》 2023年 第17卷 第12期   页码 1866-1878 doi: 10.1007/s11705-023-2340-x

摘要： Continuous glucose monitoring (CGM) systems play an increasingly vital role in the glycemic control of patients with diabetes mellitus. However, the immune responses triggered by the implantation of poorly biocompatible sensors have a significant impact on the accuracy and lifetime of CGM systems. In this review, research efforts over the past few years to mitigate the immune responses by enhancing the anti-biofouling ability of sensors are summarized. This review divided these works into active immune engaging strategy and passive immune escape strategy based on their respective mechanisms. In each strategy, the various biocompatible layers on the biosensor surface, such as drug-releasing membranes, hydrogels, hydrophilic membranes, anti-biofouling membranes based on zwitterionic polymers, and bio-mimicking membranes, are described in detail. This review, therefore, provides researchers working on implantable biosensors for CGM systems with vital information, which is likely to aid in the research and development of novel CGM systems with profound anti-biofouling properties.

关键词： implantable glucose biosensor     anti-biofouling     continuous glucose monitoring     immune responses    

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不依赖双线性对的带关键字搜索的无证书公钥加密方案构造 Research Articles

Yang LU, Ji-guo LI

《信息与电子工程前沿（英文）》 2019年 第20卷 第8期   页码 1049-1060 doi: 10.1631/FITEE.1700534

摘要： 可搜索公钥加密使存储服务器在未知数据内容时能对其存储的加密数据进行搜索，这为加密数据存储系统检索密文提供一种非常理想的解决方法。无证书公钥密码体制是一种具有许多优点的新型密码学原语，它不仅克服了基于身份密码体制中的密钥托管问题，而且避免了传统公钥密码体制中复杂的证书管理问题。目前文献中已有3个带关键字搜索的无证书公钥加密方案。然而，这些方案的构造都需要使用耗时的双线性对运算，因此不适用于计算资源受限或电量受限的设备。针对这一问题，我们设计了一个不依赖双线性对的带关键字搜索的无证书公钥加密方案。基于计算性Diffie-Hellman问题的困难性假设，我们证明所提出方案在随机预言模型中满足适应性选择关键字攻击下的密文不可区分安全性。效率对比和仿真实验表明，该方案具有更好性能。此外，我们还给出3个拓展方案。

关键词： 可搜索公钥加密；带关键字搜索的无证书公钥加密；双线性对；计算性Diffie-Hellman问题    

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标准模型下基于高效分级身份的格上加密方案 Article

Feng-he WANG,Chun-xiao WANG,Zhen-hua LIU

《信息与电子工程前沿（英文）》 2016年 第17卷 第8期   页码 781-791 doi: 10.1631/FITEE.1500219

摘要： 本文在标准模型下，利用固定维数的格基代理算法提出了一种高效的格基分级身份加密方案。其公钥尺寸仅为(dm2+mn)log q比特，而消息-密文扩展因子仅为log q，其中d为最大分级深度，(n, m, q)为公开参数。本文构造了一种新的公钥赋值算法，将1个随机、公开的矩阵平均赋值为两个身份比特，从而仅仅需要d个公开矩阵来构造标准模型下的HIBE方案；与之相比，Crypto 2010所提出的HIBE方案中需要2d个同样尺寸的矩阵，公钥尺寸达到(2dm2+mn+m)log q。为了将该方案的消息-密文扩展因子压缩到log q，本文基于Gentry的加密方案建立了一种基础加密算法，一次加密操作中能够加密m2比特明文并得到m2log q比特密文。因此，文中所提方案在公钥尺寸、消息-密文扩展因子等方面具有一定的优势。基于差错学习问题的困难性，我们证明该方案在选择身份、选择明文攻击下是安全的。

关键词： 分级身份加密；格密码；标准模型；差错学习问题；高斯    

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Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

《医学前沿（英文）》 2008年 第2卷 第2期   页码 174-177 doi: 10.1007/s11684-008-0032-z

摘要： The modulatory effect of on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type 2 diabetic patients were studied. A prospective clinical trial was conducted to test the effectiveness of in selected 201 newly diagnosed type 2 diabetic patients. All patients were randomly divided into two groups: 108 with therapy and 93 without therapy. The mean follow-up period was 22 months. The blood glucose and blood pressure of all patients were under control. Serum levels of total cholesterol (TC), triglyceride (TG), and low density lipoprotein cholesterol (LDL-C) were significantly lowered and their decreased percentages were significantly higher in therapy group ( < 0.05). The number of patients with arteria iliaca intima thickening was significantly lower in group of therapy ( = 0.024). With stepwise multivariate logistic regression analysis, the decreased percentage of TG was significantly and independently related with the decreased number of patients with arteria iliaca intima thickening ( = 0.005). The study demonstrates that therapy is effective on modulating dyslipidemia in newly diagnosed type 2 diabetes patients, and may be related with the improvement of early atherosclerosis.
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Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

《环境科学与工程前沿（英文）》 2022年 第16卷 第7期 doi: 10.1007/s11783-021-1497-0

摘要：

• Nanoparticle incorporation and anti-biofouling grafting were integrated.

关键词： Anti-biofouling grafting     Nanoparticle incorporation     Sterilization rates     Water flux     Water flux recovery    

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Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

《医学前沿（英文）》 doi: 10.1007/s11684-023-1037-3

摘要： The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous efforts to develop therapeutic agents that target severe acute respiratory syndrome coronavirus 2 to control viral infection. So far, a few small-molecule antiviral drugs, including nirmatrelvir–ritonavir (Paxlovid), remdesivir, and molnupiravir have been marketed for the treatment of COVID-19. Nirmatrelvir–ritonavir has been recommended by the World Health Organization as an early treatment for outpatients with mild-to-moderate COVID-19. However, the existing treatment options have limitations, and effective treatment strategies that are cost-effective and convenient for tackling COVID-19 are still needed. To date, four domestically developed oral anti-COVID-19 drugs have been granted conditional market approval in China. These drugs include azvudine, simnotrelvir–ritonavir (Xiannuoxin), leritrelvir, and mindeudesivir (VV116). Preclinical and clinical studies have explored the efficacy and tolerability of mindeudesivir and supported its early use in mild-to-moderate COVID-19 cases at high risk for progression. In this review, we discuss the most recent findings regarding the pharmacological mechanism and therapeutic effects focusing on mindeudesivir and other small-molecule antiviral agents for COVID-19. These findings will expand our understanding and highlight the potential widespread application of China’s homegrown anti-COVID-19 drugs.

关键词： COVID-19     antiviral drugs     mindeudesivir    

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Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

null

《医学前沿（英文）》 2012年 第6卷 第2期   页码 195-203 doi: 10.1007/s11684-012-0189-3

摘要：

The purpose of this study was to improve the dissolution rate and anti-inflammatory effect of ibuprofen by a solid dispersion (SD) method. Initial screening was developed based on drug solubility in carriers in the liquid state to select a suitable water-soluble carrier system for the preparation of SDs. The dissolution of ibuprofen in urea was higher than in PEG4000 or mannitol. Thus, urea was selected as the carrier for the preparation of SDs. SDs were characterized in terms of dissolution, differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy. Solid dispersion-based (SDBT) and conventional (CT) tablets were prepared by the wet granulation method. The anti-inflammatory effect of SDBT was evaluated using the mouse ear edema test with xylene. In vitro release results indicated that the ibuprofen dissolution rate was improved by the SD. SD characterization results suggested that ibuprofen partly precipitates in crystalline and amorphous forms after SD preparation and that ibuprofen and urea do not interact. SDBT displayed more significant anti-inflammatory effects than CT. The dissolution rate and anti-inflammatory effect of ibuprofen were significantly enhanced by the ibuprofen-urea SD.

关键词： ibuprofen     solid dispersion     physical mixture     dissolution     anti-inflammatory effect    

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标题 作者 时间 类型 操作

Lignin-derived dual-function red light carbon dots for hypochlorite detection and anti-counterfeiting

期刊论文

增值税防伪税控系统及其安全性设计

魏庆福

期刊论文

基于钻头运动诱发套管头振动信号检测的井眼防碰监测方法

何保生,刘刚,王平双,文敏

期刊论文

WLAN 802.11/11b数据加密机制的安全分析

宋宇波,胡爱群,蔡天佑

期刊论文

MULKASE：一种针对多个所有者数据的新型密钥聚合可搜索加密方法

Mukti PADHYA, Devesh C. JINWALA

期刊论文

QUANTITATIVE STUDY ON ANTI-PEST ACTIVITY OF NATURAL PRODUCTS BASED ON VISUALIZATION FRAMEWORK OF KNOWLEDGE

期刊论文

Dihydroartemisinin increased the abundance of by YAP1 depression that sensitizes hepatocellular carcinoma to anti-PD

期刊论文

A modular cable-driven humanoid arm with anti-parallelogram mechanisms and Bowden cables

期刊论文

Anti-biofouling strategies for implantable biosensors of continuous glucose monitoring systems

期刊论文

不依赖双线性对的带关键字搜索的无证书公钥加密方案构造

Yang LU, Ji-guo LI

期刊论文

标准模型下基于高效分级身份的格上加密方案

Feng-he WANG,Chun-xiao WANG,Zhen-hua LIU

期刊论文

Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

期刊论文

Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

期刊论文

Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)

期刊论文

Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion

null

期刊论文